Description
Cyclin D1 belongs to the Cyclin D family. Cyclin D1 is required for the cell cycle G1/S transition. Amplification or overexpression of Cyclin D1 plays a pivotal role in the development of various human cancers including breast cancer, colon cancer, melanoma, prostate cancer and lymphoma. It is useful to differentiate mantle cell lymphoma from small cleaved cell lymphoma. Rabbit monoclonal antibodies to Cyclin D1 showed the highest sensitivity to detect this antigen in formalin fixed paraffin embedded tissue as compared to several other clones.
Additional information
| Clone | EP12 |
|---|---|
| Isotype | Rabbit IgG |
| Immunogen | A synthetic peptide from C-terminus of human cyclin D1. |
| Species | Rabbit |
| Cellular Localization | Nuclear |
| Positive Control Tissue | Breast carcinoma |
| Pretreatment | EDTA Buffer pH 8.0 |
| Incubation & Temperature | 30 min @ RT |
| Intended Use | IVD |
| Detection System | PolyVue Plus – Two Step Detection System or Montage PolyVue Plus Auto Detection System for Montage 360 System |
| Description/Type | Conc Rabbit Monoclonal Antibody |
| Format | Purified immunoglobulin |
DATASHEETS & SDS
DATASHEETS & SDS
| Download Datasheet |
| Download SDS Sheet – OSHA |
REFERENCES
REFERENCES
- Inaba T, et al.: Genomics 1992, 13:565-574
- Bala S, et al.: Cancer Res 2001, 61:6042-6045
- Motokura T, et al.: Genes Chromosomes Cancer 1993, 7:89-95
- Pruneri G, et al.: Appl Immunohistochem Mol Morphol 2005, 13:318-322
- Dabbs DJ. Diagnostic Immunohistochemistry 2010; Churchill Livingstone
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