Description
Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed as pairs in both keratinized and non-keratinized epithelial tissue, where they constitute up to 85% of mature keratinocytes in the vertebrate epidermis. Cytokeratin 7 is expressed in epithelial cells of ovary, lung and breast. It is often used in conjunction with cytokeratin 20 and CDX-2 in distinguishing pulmonary, ovarian and breast carcinomas (CK7+) from most colon carcinomas (CK7-).
Additional information
| Clone | LP1K |
|---|---|
| Isotype | IgG1 |
| Immunogen | Sonicated cytoskeleton fractions from SV40 transformed neonatal keratinocytes |
| Species | Mouse |
| Cellular Localization | Cytoplasm |
| Positive Control Tissue | Tonsil |
| Pretreatment | HistoZyme |
| Incubation & Temperature | 30 min @ RT |
| Intended Use | IVD |
| Detection System | PolyVue Plus – Two Step Detection System or Montage PolyVue Plus Auto Detection System for Montage 360 System |
| Description/Type | Mouse Monoclonal Antibody |
| Format | This product is supplied as a tissue culture supernatant and contains sodium azide as a preservative. |
DATASHEETS & SDS
DATASHEETS & SDS
| Download Datasheet |
| Download SDS Sheet – OSHA |
REFERENCES
REFERENCES
- Moll, R., et al. 1982. The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells. Cell 31: 11-24.
- Lane, E.B., et al. 1985. Keratin antigens in differentiating skin. Ann. N.Y.Acad. Sci. 455: 241-258
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