Recognizes a protein of 120-80kDa, identified as E-cadherin. Cadherins comprise a family of Ca2+-depedent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogenesis. The c;assical cadherins, E-, N- and P-cadherin, consist of larg extracellular domains characterized by a series of five homologous NH2 terminal repeats. The relatively short intercellular domains interact with a variety of cytoplasmic proteins, such as β-catenin, to regulate cadherin function. E-cadherin plays an important role in epithelial cell adhesion. A decreased expression of E-cadherin is associated with metastatic potential and poor prognosis in breast cancer, prostate and esophageal cancer. In combination with p120 Catenin, it is useful for the differentiation between ductal (E-cadherin +) and lobular (E-cadherin -) breast carcinomas. It may also help in diagnosis of mesothelioma.
Recombinant protein encoding human Cadherin-E 600-707aa
|Positive Control Tissue
Breast carcinoma, Colon carcinoma, Appendix Cellular Localization
Citrate Buffer pH 6.0 (Manual/ Montage)
|Incubation & Temperature
30 min @ RT
PolyVue™ Plus – Two Step Detection System or Montage PolyVue Plus™ Auto Detection System for Montage 360 System or HighLighter core kit for HighLighter Staining System
Mouse Monoclonal Antibody
This product is supplied as an ascites fluid. It contains sodium azide as a preservative.
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