Description
This antibody recognizes a protein of ~50kDa which is identified as Glial Fibrillary Acidic Protein (GFAP). It shows no cross-reaction with other intermediate filament proteins. GFAP is specifically found in astroglia. GFAP is a very popular marker for localizing benign astrocyte and neoplastic cells of glial origin in the central nervous system. Antibody to GFAP is useful in differentiating primary gliomas from metastatic lesions in the brain and for documenting astrocytic differentiation in tumors outside the CNS.
Additional information
| Clone | GA5 |
|---|---|
| Isotype | IgG1, kappa |
| Immunogen | BALB/C mice were immunized with glial fibrillary protein from porcine spinal cord. |
| Species | Mouse |
| Cellular Localization | Cytoplasmic |
| Positive Control Tissue | Brain |
| Pretreatment | Citrate Buffer pH 6.0 (Manual/ Montage) |
| Incubation & Temperature | 30 min @ RT |
| Intended Use | IVD |
| Detection System | PolyVue™ Plus – Two Step Detection System or Montage PolyVue Plus™ Auto Detection System for Montage 360 System or HighLighter core kit for HighLighter Staining System |
| Description/Type | Mouse Monoclonal Antibody |
| Format | This product is supplied as a purified immunoglobulin and contains sodium azide as a preservative. |
DATASHEETS & SDS
DATASHEETS & SDS
| Download Datasheet |
| Download SDS Sheet – OSHA |
REFERENCES
REFERENCES
- Herpers M1 et at 1986, Acta Netropatficl, 70:333-339.
- Van Muilen GN et. at 1987, Lab Invest, 57:359-369.
- Debts E, et. ot 1983, Differentiation, 25421:193-203.
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