Description
HHV 8 encodes a latent nuclear antigen (LNA), which is the product of the viral gene orf 73. LNA is capable of forming a complex with retinoblastoma susceptibility gene product, which may be related to its oncogenic activity. HHV8 is associated with three different diseases observed in AIDS patients; kaposi’s sarcoma, primary effusion lymphoma (which is a rare type of nonHodgkin lymphoma affecting the body cavities), and multicentric Castleman’s disease. HHV 8 is the likely etiological agent of Kaposi’s sarcoma.
Additional information
| Clone | LN53 |
|---|---|
| Isotype | IgG3 |
| Immunogen | Recombinant protein corresponding to the latent nuclear antigen-1 molecule of HHV8. |
| Species | Rat |
| Cellular Localization | Nuclear |
| Positive Control Tissue | Karposi sarcoma |
| Pretreatment | EDTA Buffer pH 8.0 |
| Incubation & Temperature | 30 min @ RT |
| Intended Use | IVD, RUO |
| Detection System | PolyVue Plus – Two Step Detection System or Montage PolyVue Plus Auto Detection System for Montage 360 System |
| Description/Type | Rat Monoclonal Antibody |
| Format | Tissue Culture Supernatant |
DATASHEETS & SDS
REFERENCES
REFERENCES
- i) Ablashi et al. Clinc Microbiol Reviews 15: 439, 2002
- ii) Dupin et al. Proc. Natl. Acad. Sci. USA 96: 4546, 1999.
- iii) Kellam et al. J Virol 73: 5149, 1999.
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