Description
Cell cycle-dependent protein kinase inhibitor P16 is a protein that can negatively regulate the cell cycle. HPV persistent infection causes overexpression of P16, but P16 expression is also present in normal cells. P16 is of great significance for the screening of cervical cancer, but by itself may not be sufficient for diagnosis. Ki-67 is a nuclear antigen that can be detected in the non-G0 phase of the cell cycle, marking the process of cell proliferation. For normal tissues, the simultaneous expression of P16 and Ki-67 is less likely to occur. Combined detection of Ki-67 and P16 protein has a high application prospect as an auxiliary identification of cervical intraepithelial neoplasia and squamous cell carcinoma.
Additional information
| Catalog No. | PDRMM001 |
|---|---|
| Clone | SP6 / JC2 |
| Species | Rabbit + Mouse |
| Isotype | Rabbit IgG / IgG2a |
| Immunogen | Synthetic peptide from 62 base pair region of the human Ki-67 antigen. And purified recombinant prokaryotic full length human P16 INK4 protein |
| Positive Control Tissue | Cervical CA |
| Pretreatment | EDTA Buffer pH 8.0 |
| Incubation & Temperature | 30 min @ RT |
| Intended Use | IVD (Outside Europe) |
| Detection System | PolyVue™ Plus – Two Step Detection System or Montage PolyVue Plus™ Auto Detection System for Montage 360 System |
| Format | This product is supplied as a purified immunoglobulin and contains sodium azide as a preservative. |
| Description/Type | Rabbit Monoclonal anti-ki67 + Mouse Monoclonal anti-p16 |
DATASHEETS & SDS
DATASHEETS & SDS
| Download Datasheet |
| Download SDS Datasheet |
REFERENCES
REFERENCES
- Adisorn Jedpiyawongse et al. Immunohistochemical overexpression of p16 protein associated with cervical cancer in Thailand. Asian Pac J Cancer Prev. Oct-Dec 2008;9(4):625-30.
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