Description
MCM7 is one of the highly conserved mini-chromosome maintenance proteins (MCM) that is essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possess DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumor suppressor protein RB1/RB.
Additional information
| Catalog No. | Mob612, Mob612-01, Mob612-05, PDM612 |
|---|---|
| Clone | MCM7/1466 |
| Species | Mouse |
| Isotype | IgG1 |
| Immunogen | Recombinant human MSM7 protein fragment |
| Positive Control Tissue | Tonsil |
| Pretreatment | EDTA Buffer pH 8.0 |
| Incubation & Temperature | 30 min @ RT |
| Intended Use | IVD (Outside Europe) |
| Format | Purified immunoglobulin and contains sodium azide as a preservative. |
| Description/Type | PolyVue™ Plus – Two Step Detection System or Montage PolyVue Plus™ Auto Detection System for Montage 360 System |
DATASHEETS & SDS
DATASHEETS & SDS
| Download Datasheet |
| Download SDS Sheet – OSHA |
REFERENCES
REFERENCES
- Koonin, E.V. 1993. A common set of conserved motifs in a vast variety of
putative nucleic acid-dependent ATPases including MCM proteins
involved in the initiation of eukaryotic DNA replication. Nucleic Acids Res.
21: 2541-2547.
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