Description
O(6)-methylguanine-DNA-methyltransferase (MGMT) is a 22 kDa human DNA repair protein that removes O(6)-alkylguanine DNA adducts. MGMT acts as a suicide acceptor protein repairing the DNA by accepting alkyl groups and consequently inactivating itself. This antibody stains all mantle zone lymphocytes and 50% of germinal center lymphocytes. Basaloid epithelial cells of tonsilsquamous mucosa are also stained positive with this antibody.
Additional information
| Clone | MT3.1 |
|---|---|
| Isotype | IgG1 |
| Immunogen | Recombinant human MGMT protein. |
| Species | Mouse |
| Cellular Localization | Cytoplasmic, Nuclear |
| Positive Control Tissue | Tonsil |
| Pretreatment | Citrate Buffer pH 6.0 |
| Incubation & Temperature | 30 min @ RT |
| Intended Use | IVD |
| Detection System | PolyVue Plus – Two Step Detection System or Montage PolyVue Plus Auto Detection System for Montage 360 System |
| Description/Type | Mouse Monoclonal Antibody |
| Format | This product is supplied as a purified immunoglobulin and contains sodium azide as a preservative. |
DATASHEETS & SDS
DATASHEETS & SDS
| Download Datasheet |
| Download SDS Sheet – OSHA |
REFERENCES
REFERENCES
- Egyhazi et al. Br J Cancer 71: 37, 1995.
- Gerson et al. J Clin Oncol 20: 2388, 2002.
- Matsukura et al. Annals Surg Oncol 8: 807, 2001.
Reviews (0)
Only logged in customers who have purchased this product may leave a review.
Reviews
There are no reviews yet.