Description
The homeodomain-containing transcription factor NKX3-1 is a putative prostate tumorsuppressorthatis expressed in a largely prostate-specific and androgen-regulated manner. Loss of NKX3-1 protein expression is a common finding in human prostate carcinomas and prostatic intraepithelial neoplasia.
Additional information
| Catalog No. | Mob569 Concentrated, PDM569 Prediluted |
|---|---|
| Clone | 361 |
| Isotype | IgG1 k |
| Immunogen | Recombinant His fusion protein corresponding to full length human NKX3-1 |
| Species | Mouse |
| Cellular Localization | Cytoplasm |
| Positive Control Tissue | Prostate cancer |
| Pretreatment | EDTA Buffer pH 8.0 |
| Incubation & Temperature | 30 min @ RT |
| Intended Use | IVD |
| Detection System | PolyVue Plus – Two Step Detection System or Montage PolyVue Plus Auto Detection System for Montage 360 System |
| Description/Type | Mouse Monoclonal Antibody |
| Format | Tissue Culture Supernatant |
DATASHEETS & SDS
DATASHEETS & SDS
| Download Datasheet |
| Download SDS Sheet – OSHA |
REFERENCES
REFERENCES
- Gao H et al. A critical role for p27kip1 gene dosage in a mouse model of prostate carcinogenesis Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17204-9. Epub 2004 Nov 29.
- Kim MJ, et al. Cooperativity of Nkx3.1 and Pten loss of function in a mouse model of prostate carcinogenesis. Proc Natl Acad Sci U S A. 2002 Mar 5;99 (5):2884-9. Epub 2002 Feb 19.
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