p63/p504s Cocktail

p63 is a homolog of the tumor suppressor p53. It is identified in basal cells in the epithelial layers of a variety of tissues, including epidermis, cervix, urothelium, breast and prostate. p63, vital for the development of the prostate and selectively expressed by normal prostate basal cells, has been shown useful in the differential diagnosis of benign prostatic lesions and prostatic carcinoma. p63 has also been shown to be highly sensitive and specific for detecting lung squamous cell carcinomas of the breast. p63 staining can be identified in myoepithelial cells of normal ducts. The expression of p504S protein is found in prostatic adenocarcinoma. It stains premalignant lesions of prostate: high-grade prostatic intraepithelial neoplasia (PIN) and atypical adenomatous hyperplasia. P504S can be used as a positive marker for PIN.

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REFERENCES

I. Yang A, et al. p63, a p53 homolog at 3q27–29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. Mol Cell. 1998 Sep; 2(3):305-16.
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