Pan-TRK

Neurotrophic tyrosine kinase receptor (NTRK) is a family of 3 proto-oncogenes including NTRK1, NTRK2, and NTRK3 which encode Trk A, Trk B, and Trk C proteins, respectively. The latter are involved in biological processes such as neuronal survival, differentiation, and plasticity under physiological circumstances. In various cancers, oncogenic fusionsinvolving the kinase domain of NTRK1, 2, or 3 are present. Pan-Trk IHC is a time- and tissue-efficient screen for NTRK fusions, particularly in driver-negative advanced malignancies and potential cases of secretory carcinoma and congenital fibrosarcoma. Pan-Trk IHC can help determine whether translation occurs for novel NTRK rearrangements.

DATASHEETS & SDS

REFERENCES

• Nakagawara A. Trk receptor tyrosine kinases: a bridge between cancer and neural development. Cancer Lett2001;169:107–14. 10.1016/S0304- 3835(01)00530-4
• Huang EJ, et al. Trk receptors: roles in neuronal signal transduction. Annu Rev Biochem2003;72:609–42. 10.1146/annurev.biochem.72.121801.161629
• Laé M, et al. Secretory breast carcinomas with ETV6-NTRK3 fusion gene belong to the basal-like carcinoma spectrum. Mod Pathol. 2009 Feb; 22(2):291–8.
• Sheng WQ, et al. Congenital-infantile fibrosarcoma. A clinicopathologic study of 10 cases and molecular detection of the ETV6-NTRK3 fusion transcripts using paraffinembedded tissues. Am J Clin Pathol. 2001; 115(3):348–355.