Description
PTEN gene is a tumor suppressor gene that maps to chromosome 10q23. PTEN, a novel tumor suppressor, functions as a regulator of both cell cycle progression and apoptosis ). Potentially, mutation and deletion of PTEN gene may result in a new signal transduction pathway related to human malignant tumors. Studies have demonstrated a reduction of PTEN expression in advanced breast cancers
Additional information
| Catalog No. | Mob574 Concentrated, PDM574 Prediluted |
|---|---|
| Clone | 6H2.1 |
| Isotype | IgG2a |
| Immunogen | C-terminal 100 amino acids of PTEN |
| Species | Mouse |
| Cellular Localization | Nuclear and Cytoplasmic |
| Positive Control Tissue | Breast, Renal cell and Prostate carcinomas |
| Pretreatment | EDTA Buffer pH 8.0 |
| Incubation & Temperature | 30 min @ RT |
| Intended Use | IVD |
| Detection System | PolyVue Plus – Two Step Detection System or Montage PolyVue Plus Auto Detection System for Montage 360 System |
| Description/Type | Mouse Monoclonal Antibody |
| Format | Tissue Culture Supernatant |
DATASHEETS & SDS
DATASHEETS & SDS
| Download Datasheet |
| Download SDS Sheet – OSHA |
REFERENCES
REFERENCES
- Bose S, et al. Reduced expression of PTEN correlates with breast cancer progression. Hum Pathol. 2002 Apr; 33(4):405-9.
- Bose S, et al. The Akt pathway in human breast cancer: a tissuearray-based analysis. Mod Pathol. 2006 Feb;19(2):238-45..
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