The family of EF-hand type Ca2+ -binding proteins includes calbindin, S-100 alpha and beta, calgranulins, B and C, and the parvalbumin family members, including parvalbumin alpha and parvalbumin beta. The S-100 protein is involved in the regulation of cellular processes such as cell cycle progression and differentiation. S-100 protein may function in the activation of Ca2+ induced Ca2+ release, inhibition of microtubule assembly and inhibition of protein kinase C mediated phosphorylation. Two S-100 subunits, sharing 60% sequence identity, have been described as S-100 alpha chain and S-100 beta chain. Three S-100 dimeric forms have been characterized, differing in their subunit composition of two alpha chains, two beta chains or one alpha and one beta chain. S-100 localizesto the cytoplasm and nuclei of astrocytes, Schwann’s cells, ependymomas and astrogliomas. S-100 is also detected in almost all benign naevi, malignant melanocytic tumours and in Langerhans cellsin the skin. Calbindin, S-100 proteins and parvalbumin proteins are each expressed in neural tissues. In addition, S-100 alpha and beta are present in a variety of other tissues and calbindin is present in intestine and kidney.
PDR008 Prediluted, RP035 Concentrated
Recombinant Full length Human S100A1 protein.
|Positive Control Tissue
Citrate Buffer pH 6.0
|Incubation & Temperature
30 min @ RT
PolyVue Plus – Two Step Detection System or Montage PolyVue Plus Auto Detection System for Montage 360 System
Rabbit Polyclonal Antibody
Purified immunoglobulin fraction ofrabbit antiserum against S-100 containing sodium azide as a preservative.
- Heizman. C.W.1988. Calcium-bindin proteins of the EF-type. J.
Cardiovasc. Pharmacol. 5:S30-S37.
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