SMADs are members of the MAD-related family of molecules. MAD-related proteins are a family of intracellular proteins that are essential components in the signaling pathways of the serine/threonine kinase receptors of the transforming growth factor beta superfamily. Alterations in the SMAD4 gene was primarily discovered in pancreatic cancer (duct adenocarcinoma) but occur in a variety of cancers such as colorectal cancer, gastric cancer, prostate cancer, melanomas, head and neck cancers and many others, though with higher frequencies in gastrointestinal tract cancers. Loss of SMAD4 expression in tumors has also been shown to affect cancer progression and therapy, such as reduced response to adjuvant chemotherapy.
PDR173 Prediluted, RP173 Concentrated
Recombinant fragment corresponding to a region within amino acids 322 and 552 of SMAD4
|Positive Control Tissue
Colon Ca, Pancreas Ca
EDTA (pH 8.0)
|Incubation & Temperature
30 min @ RT
PolyVue Plus – Two Step Detection System or Montage PolyVue Plus Auto Detection System for Montage 360 System
Rabbit Polyclonal Antibody
Purified immunoglobulin fraction ofrabbit antiserum containing sodium azide as a preservative.
- Shi S et al. Metabolic tumor burden is associated with major oncogenomic alterations and serum tumor markers in patients with resected pancreatic cancer. Cancer Lett 360:227-33 (2015). IHC ; Human
- Shi Y, et.al. A structural basis for mutational inactivation of the tumour suppressor Smad4. Nature. 1997;388:87–93.The first crystal structure of a Smad domain, the Smad4 MH2.
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