Description
Thyroid peroxidase (TPO) is a transmembrane protein of 107kDa containing a heme prosthetic group. It is present as a dimer on the apical surface of thyroid follicular cells. TPO is the primary enzyme involved in thyroid hormone synthesis. Malignant thyroid tumors exhibit an anomaly in TPO resulting in lower affinity for anti-TPO. This antibody may aid in the differentiation between benign and malignant thyroid tumors.
Additional information
| Catalog No. | Mob418 Concentrated |
|---|---|
| Clone | MoAb47 |
| Isotype | IgG1, kappa |
| Immunogen | Recobinant human TPO fragment around aa 685-804 (Exact sequence is proprietary) |
| Species | Mouse |
| Cellular Localization | Cytoplasmic |
| Positive Control Tissue | Thyroid |
| Pretreatment | EDTA Buffer pH 8.0 |
| Incubation & Temperature | 30 min @ RT |
| Intended Use | IVD |
| Detection System | PolyVue Plus – Two Step Detection System or Montage PolyVue Plus Auto Detection System for Montage 360 System |
| Description/Type | Mouse Monoclonal Antibody |
| Format | Tissue Culture Supernatant |
DATASHEETS & SDS
DATASHEETS & SDS
| Download Datasheet |
| Download SDS Sheet – OSHA |
REFERENCES
REFERENCES
- Fayadat, L., et al. 1998. Human Thyroperoxidase is largly retained and
rapidly degraded in the endoplasmic reticulum. Its N-glycans are
required for folding and intracellular trafficking. Endocrinology
139:4277-4285.
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