Description
Villin is One of the gelsolin family of calcium regulated actin binding proteins. Normally expressed in the brush border of epithelial cells lining the gastrointestinal tract, hepatobiliary tract and renal proximal convoluted tubules. In colorectal carcinoma, villin is highly expressed. In practice, villin can be included in the panel used for metastatic carcinoma to detect colorectal origin.
Additional information
| Catalog No. | Mob590 Concentrated, PDM590 Prediluted |
|---|---|
| Clone | 1D2C3 |
| Isotype | IgG1, kappa |
| Immunogen | Raised against purified full length native Villin of chicken origin |
| Species | Mouse |
| Cellular Localization | Apical membranous (brush border)/ Cytoplasmic |
| Positive Control Tissue | Small intestine, Colorectal carcinoma |
| Pretreatment | EDTA Buffer pH 8.0 |
| Incubation & Temperature | 30 min @ RT |
| Intended Use | IVD |
| Detection System | PolyVue Plus – Two Step Detection System or Montage PolyVue Plus Auto Detection System for Montage 360/HighLighter System |
| Description/Type | Mouse Monoclonal Antibody |
| Format | This product is supplied as a immunoglobulin and contains sodium azide as a preservative. |
DATASHEETS & SDS
DATASHEETS & SDS
| Download Datasheet |
| Download SDS Sheet – OSHA |
REFERENCES
REFERENCES
- Onozato, D., et al. 2018. Generation of intestinal organoids suitable for pharmacokinetic studies from human induced pluripotent stem cells. Drug Metab. Dispos. 46: 1572-1580.
- Sim, H., et al. 2020. Iroquois homeobox protein 2 identified as a potential biomarker for parkinson’s disease. Int. J. Mol. Sci. 21: 3455.
- Diego Arango, et al. Villin expression is frequently lost in poorly differentiated colon cancer. Am J Pathol. 2012 Apr;180(4):1509-21
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