Description
Wilm’s Tumor (WT1), is a gene involved in the induction of Wilm’s Tumor, a sporadic and familial pediatric kidney tumor. Wilm’stumor is associated with mutations of WT1, a zinc-finger transcription factor that is essential for the development of the metanephric kidney and the urogenitalsystem. The WT1 gene is normally expressed in fetal kidney and mesothelium, and its expression has been suggested as a marker for Wilm’s tumor and mesothelioma. WT1 has been identified in proliferative mesothelial cells, malignant mesothelioma, ovarian carcinoma, gonadoblastoma, nephroblastoma, and desmoplastic small round cell tumor.
Additional information
| Catalog No. | Mob437 Concentrated, PDM177 Prediluted |
|---|---|
| Clone | 6F-H2 |
| Isotype | IgG1, kappa |
| Immunogen | Protein G Purified monoclonal antibody from Cl1000 in vitro production |
| Species | Mouse |
| Cellular Localization | Cytoplasmic, Nuclear |
| Positive Control Tissue | Wilms Tumor and Mesothelioma |
| Pretreatment | EDTA Buffer pH 8.0 |
| Incubation & Temperature | 30 min @ RT |
| Intended Use | IVD |
| Detection System | PolyVue Plus – Two Step Detection System or Montage PolyVue Plus Auto Detection System for Montage 360 System |
| Description/Type | Mouse Monoclonal Antibody |
| Format | Purified immunoglobulin |
DATASHEETS & SDS
DATASHEETS & SDS
| Download Datasheet |
| Download SDS Sheet – OSHA |
REFERENCES
REFERENCES
- Haber et al. New Biol 4:97, 1992.
- Kumar-Singh etal. I Pat hol 181: 67, 1997.
- Menssen et of. Leukemia: 1060, 1995
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