Description
p120 Catenin associates with the cytoplasmic portion of E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecule. In normal tissues, p120 catenin is localized to the membrane of epithelial cells, consistent with its role in the cell adhesion complex. In breast ductal neoplasia, p120 catenin is usually localized in cellular membranes. However, in lobular neoplasia, a marked redistribution of p120 catenin throughout the cytoplasm results in a diffuse cytoplasmic pattern. Immune-staining of p120 catenin and E-cadherin helps in the accurate identification of ductal and lobular neoplasms, including a distinction between low-grade ductal carcinoma in sito (DCIS) and lobular carcinoma. Additionally, some rectal and gastric adenocarcinomas demonstrate diffuse cytoplasmic p120 catenin staining and a lack of membranous staining, mimicking the staining pattern observed with lobular breast carcinomas.
Additional information
| Catalog No. | Mob529, PDM529 |
|---|---|
| Clone | DBM15.55 |
| Isotype | IgG1, kappa |
| Immunogen | Recombinant human p120 Catenin protein fragment |
| Species | Mouse |
| Cellular Localization | cell surface, Cytoplasmic |
| Positive Control Tissue | Breast carcinoma |
| Pretreatment | EDTA Buffer pH 8.0 |
| Incubation & Temperature | 30 min @ RT |
| Intended Use | IVD |
| Detection System | PolyVue™ Plus – Two Step Detection System or Montage PolyVue Plus™ Auto Detection System for Montage 360 System |
| Description/Type | Mouse Monoclonal Antibody |
| Format | This product is supplied as a purified immunoglobulin and contains sodium azide as a preservative. |
DATASHEETS & SDS
DATASHEETS & SDS
| Download Datasheet |
| Download SDS Sheet – OSHA |
REFERENCES
REFERENCES
- Dabbs DJ et. al. Am J Surg Path. 2007;31:427-437.
- Sarrio D et. al. Oncogene. 2004;23:3272-3283.
- Mastracci TL et. al. Mod Path. 2005;18:741-751.
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